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Search: WFRF:(Jacobsen Sten Eirik W) > Hellström Lindberg Eva > Jädersten Martin > Patient-Specific Me...

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Patient-Specific Measurable Residual Disease Markers Predict Outcome in Patients With Myelodysplastic Syndrome and Related Diseases After Hematopoietic Stem-Cell Transplantation

Tobiasson, Magnus (author)
Department of Hematology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Centre for Hematology and Regenerative Medicine (HERM), Karolinska Institute, Stockholm, Sweden
Pandzic, Tatjana (author)
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Illman, Johanna (author)
Division of Hematology, Helsinki University Hospital, Comprehensive Cancer Center, Helsinki, Finland
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Nilsson, Lars (author)
Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Lund, Sweden
Weström, Simone (author)
Karolinska Institutet
Ejerblad, Elisabeth (author)
Unit of Haematology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Olesen, Gitte (author)
Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
Björklund, Andreas (author)
Karolinska Institutet
Olsnes Kittang, Astrid (author)
Department of Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway
Werlenius, Olle (author)
Section of Hematology and Coagulation, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Lorentz, Fryderyk (author)
Department of Hematology, Norrlands University Hospital, Umeå, Sweden
Rasmussen, Bengt, 1970- (author)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Cammenga, Jörg (author)
Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Lund, Sweden; Division of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden
Weber, Duruta (author)
Department of Hematology, Odense University Hospital, Odense, Denmark
Lindholm, Carolin (author)
Department of Hematology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Centre for Hematology and Regenerative Medicine (HERM), Karolinska Institute, Stockholm, Sweden
Wiggh, Joel (author)
Department of Hematology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Centre for Hematology and Regenerative Medicine (HERM), Karolinska Institute, Stockholm, Sweden
Dimitriou, Marios (author)
Karolinska Institutet
Moen, Ann Elin (author)
Department of Hematology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Yip Lundström, Laimei (author)
Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
von Bahr, Lena (author)
Section of Hematology and Coagulation, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Baltzer-Sollander, Karin (author)
Department of Genetics, HUS Diagnostic Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Jädersten, Martin (author)
Department of Hematology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Centre for Hematology and Regenerative Medicine (HERM), Karolinska Institute, Stockholm, Sweden
Kytölä, Soili (author)
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
Walldin, Gunilla (author)
Department of Medicine, Huddinge, Centre for Hematology and Regenerative Medicine (HERM), Karolinska Institute, Stockholm, Sweden
Ljungman, Per (author)
Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska Comprehensive Cancer Center, Karolinska University Hospital Huddinge, Stockholm, Sweden
Groenbaek, Kirsten (author)
Department of Hematology, Rigshospitalet, Copenhagen, Copenhagen, Denmark
Mielke, Stephan (author)
Karolinska Institutet
Jacobsen, Sten Eirik W. (author)
Department of Medicine, Huddinge, Centre for Hematology and Regenerative Medicine (HERM), Karolinska Institute, Stockholm, Sweden
Ebeling, Freja (author)
Division of Hematology, Helsinki University Hospital, Comprehensive Cancer Center, Helsinki, Finland
Cavelier, Lucia (author)
Department of Genetics, HUS Diagnostic Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Smidstrup Friis, Lone (author)
Department of Hematology, Rigshospitalet, Copenhagen, Copenhagen, Denmark
Dybedal, Ingunn (author)
Department of Hematology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Hellström-Lindberg, Eva (author)
Department of Hematology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Centre for Hematology and Regenerative Medicine (HERM), Karolinska Institute, Stockholm, Sweden
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 (creator_code:org_t)
2024
2024
English.
In: Journal of Clinical Oncology. - : American Society of Clinical Oncology. - 0732-183X .- 1527-7755. ; , s. JCO2301159-
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
http://kipublication...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • PURPOSE: Clinical relapse is the major threat for patients with myelodysplastic syndrome (MDS) undergoing hematopoietic stem-cell transplantation (HSCT). Early detection of measurable residual disease (MRD) would enable preemptive treatment and potentially reduced relapse risk.METHODS: Patients with MDS planned for HSCT were enrolled in a prospective, observational study evaluating the association between MRD and clinical outcome. We collected bone marrow (BM) and peripheral blood samples until relapse, death, or end of study 24 months after HSCT. Patient-specific mutations were identified with targeted next-generation sequencing (NGS) panel and traced using droplet digital polymerase chain reaction (ddPCR).RESULTS: Of 266 included patients, estimated relapse-free survival (RFS) and overall survival (OS) rates 3 years after HSCT were 59% and 64%, respectively. MRD results were available for 221 patients. Relapse was preceded by positive BM MRD in 42/44 relapses with complete MRD data, by a median of 71 (23-283) days. Of 137 patients in continuous complete remission, 93 were consistently MRD-negative, 39 reverted from MRD+ to MRD-, and five were MRD+ at last sampling. Estimated 1 year-RFS after first positive MRD was 49%, 39%, and 30%, using cutoff levels of 0.1%, 0.3%, and 0.5%, respectively. In a multivariate Cox model, MRD (hazard ratio [HR], 7.99), WHO subgroup AML (HR, 4.87), TP53 multi-hit (HR, 2.38), NRAS (HR, 3.55), and acute GVHD grade III-IV (HR, 4.13) were associated with shorter RFS. MRD+ was also independently associated with shorter OS (HR, 2.65). In a subgroup analysis of 100 MRD+ patients, presence of chronic GVHD was associated with longer RFS (HR, 0.32).CONCLUSION: Assessment of individualized MRD using NGS + ddPCR is feasible and can be used for early detection of relapse. Positive MRD is associated with shorter RFS and OS (ClinicalTrials.gov identifier: NCT02872662).

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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